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Rigosertib sodium

CAS No. 592542-60-4

Rigosertib sodium ( ON-01910 sodium;ON01910 sodium;ON01910 sodium )

Catalog No. M15194 CAS No. 592542-60-4

Rigosertib sodium (ON 01910.Na) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rigosertib sodium
  • Note
    Research use only, not for human use.
  • Brief Description
    Rigosertib sodium (ON 01910.Na) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10 nM).
  • Description
    Rigosertib sodium (ON 01910.Na) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10 nM), selectively induces mitotic G2/M arrest and apoptosis in cancer cells; also exhibits inhibitory activity against PDGFR, Abl, and Flt-1, at higher concentrations, inhibits CDK1, Plk2, Src, and Fyn; demonstrates in vitro cytotoxicity against DU145 and K562 cells with IC50 of 100 and 15 nM; potently inhibits tumor growth in a variety of xenograft nude mouse models, does not exhibit hematotoxicity, liver damage, or neurotoxicity shows strong synergy with several chemotherapeutic agents.Blood Cancer Phase 3 Clinical
  • Synonyms
    ON-01910 sodium;ON01910 sodium;ON01910 sodium
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PLK
  • Recptor
    PLK
  • Research Area
    Cancer
  • Indication
    Blood cancer

Chemical Information

  • CAS Number
    592542-60-4
  • Formula Weight
    473.47
  • Molecular Formula
    C21H24NNaO8S
  • Purity
    >98% (HPLC)
  • Solubility
    H2O: ≥ 52 mg/mL
  • SMILES
    COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
  • Chemical Name
    Glycine, N-[2-methoxy-5-[[[(1E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, sodium salt (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Reddy MV, et al. J Med Chem. 2011 Sep 22;54(18):6254-76.
2. Gumireddy K, et al. Cancer Cell. 2005 Mar;7(3):275-86.
3. Oussenko IA, et al. Cancer Res. 2011 Jul 15;71(14):4968-76.
4. Chun AW, et al. Cancer Chemother Pharmacol. 2009 Dec;65(1):177-86.
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